Chapter

cGMP: Generators, Effectors and Therapeutic Implications

Volume 191 of the series Handbook of Experimental Pharmacology pp 111-136

Cyclic Nucleotide-Gated Channels

  • Martin BielAffiliated withCenter for Integrated Protein Science CIPS-M and Zentrum für Pharmaforschung — Department Pharmazie, Pharmakologie für Naturwissenschaften, Ludwig-Maximilians-Universität München Email author 
  • , Stylianos MichalakisAffiliated withCenter for Integrated Protein Science CIPS-M and Zentrum für Pharmaforschung — Department Pharmazie, Pharmakologie für Naturwissenschaften, Ludwig-Maximilians-Universität München

Abstract

Cyclic nucleotide-gated (CNG) channels are ion channels which are activated by the binding of cGMP or cAMP. The channels are important cellular switches which transduce changes in intracellular concentrations of cyclic nucleotides into changes of the membrane potential and the Ca2+ concentration. CNG channels play a central role in the signal transduction pathways of vision and olfaction. Structurally, the channels belong to the superfamily of pore-loop cation channels. They share a common domain structure with hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and Eag-like K+ channels. In this chapter, we give an overview on the molecular properties of CNG channels and describe the signal transduction pathways these channels are involved in. We will also summarize recent insights into the physiological and pathophysiological role of CNG channel proteins that have emerged from the analysis of CNG channel-deficient mouse models and human channelopathies.

Keywords

CNG Cyclic nucleotide-gated channel Channelopathies Knockout cGMP cAMP