An Integration of Old and New Perspectives of Mammalian Meiotic Sterility

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Male sterility arises when an individual produces an insufficient number of functional sperm to ensure fertilization. Obviously, mutations in structural proteins can lead to misshapen or immobile sperm that result in infertility. This review, however, will focus on disruptions in the meiotic process that lead to cell death during meiosis or early spermatogenesis. In other words, it will focus on events that occur prior to the differentiation and maturation of the haploid gametes into sperm.