Chapter

World Congress on Medical Physics and Biomedical Engineering 2006

Volume 14 of the series IFMBE Proceedings pp 1667-1671

Limit of Spatial Resolution in FDG-PET due to Annihilation Photon Non-Collinearity

  • Kengo ShibuyaAffiliated withMolecular Imaging Center, National Institute of Radiological Sciences Email author 
  • , E. YoshidaAffiliated withMolecular Imaging Center, National Institute of Radiological Sciences
  • , F. NishikidoAffiliated withMolecular Imaging Center, National Institute of Radiological Sciences
  • , T. SuzukiAffiliated withResearch Center for Radiation Emergency Medicine, National Institute of Radiological Sciences
  • , T. TsudaAffiliated withMolecular Imaging Center, National Institute of Radiological Sciences
  • , N. InadamaAffiliated withMolecular Imaging Center, National Institute of Radiological Sciences
  • , T. YamayaAffiliated withMolecular Imaging Center, National Institute of Radiological Sciences
  • , H. MurayamaAffiliated withMolecular Imaging Center, National Institute of Radiological Sciences

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Abstract

We provide a new viewpoint for a fundamental but little investigated problem in positron emission tomography (PET): non-collinearity of annihilation radiation from the human body. The cause of the angular deviation from 180 deg is described as well as how to evaluate it under a spatially distributed radiation source and a limited acquisition time. An elegant conversion from the photopeak spectrum into the angular distribution is done based on the conservation laws of momentum and energy to avoid problems in the direct measurement. A healthy volunteer study using 18FDG and a Ge semiconductor detector reveals the distribution as a Gaussian function with the FWHM of 0.54 deg. Finally, we calculate the physical limit of 18FDG-PET spatial resolution.

Keywords

angular deviation in vivo study spatial resolution Doppler Effect Ge semiconductor detector