Dermatological Phototherapy and Photodiagnostic Methods

pp 135-149

Photo(chemo)therapy for Cutaneous T-Cell Lymphoma

  • Herbert HönigsmannAffiliated withDermatologische Klinik Abt. Spezielle Dermatologie, Universitätsklinikum Wien Email author 
  • , Adrian TanewAffiliated withDepartment of Dermatology, Division of Special & Environmental Dermatology, Medical University of Vienna

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› Cutaneous T-cell lymphoma (CTCL) encompasses a heterogeneous group of non-Hodgkin lymphomas that present primarily in skin.

› Because of clinical heterogeneity, treatment options for CTCL are also diverse, and treatment with more than one modality is common.

› Many patients with CTCL present with disease limited to the skin, providing ideal circumstances for the use of any one of several types of phototherapy, with or without additional therapies.

› Three phototherapies have been employed to treat CTCL with considerable success: (1) conventional broad-spectrum UVB irradiation, (2) UVA irradiation in combination with a systemically administered photosensitizing drug, such as 8-methoxypsoralen, and (3) UVA irradiation in combination with a topically administered photosensitizing drug.

› Successful phototherapy of patients with CTCL may lead to long-term remission and potentially even a cure.