Chapter

Transient Receptor Potential (TRP) Channels

Volume 179 of the series Handbook of Experimental Pharmacology pp 593-614

Phospholipase C-Coupled Receptors and Activation of TRPC Channels

  • M. TrebakAffiliated withLaboratory of Signal Transduction, Department of Health and Human Services, National Institute of Environmental Health Sciences—NIH
  • , L. LemonnierAffiliated withLaboratory of Signal Transduction, Department of Health and Human Services, National Institute of Environmental Health Sciences—NIH
  • , J. T. SmythAffiliated withLaboratory of Signal Transduction, Department of Health and Human Services, National Institute of Environmental Health Sciences—NIH
  • , G. VazquezAffiliated withLaboratory of Signal Transduction, Department of Health and Human Services, National Institute of Environmental Health Sciences—NIH
  • , J. W. PutneyJr.Affiliated withLaboratory of Signal Transduction, Department of Health and Human Services, National Institute of Environmental Health Sciences—NIH

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Abstract

The canonical transient receptor potential (TRPC) cation channels are mammalian homologs of the photoreceptor channel TRP in Drosophila melanogaster. All seven TRPCs (TRPC1 through TRPC7) can be activated through Gq/11 receptors or receptor tyrosine kinase (RTK) by mechanisms downstream of phospholipase C. The last decade saw a rapidly growing interest in understanding the role of TRPC channels in calcium entry pathways as well as in understanding the signal(s) responsible for TRPC activation. TRPC channels have been proposed to be activated by a variety of signals including store depletion, membrane lipids, and vesicular insertion into the plasma membrane. Here we discuss recent developments in the mode of activation as well as the pharmacological and electrophysiological properties of this important and ubiquitous family of cation channels.

Keywords

Ion channels TRPC channels Nonselective cation channel Store-operated channel Phospholipase C