Chapter

Analgesia

Volume 177 of the series Handbook of Experimental Pharmacology pp 217-249

Glutamate Receptor Ligands

  • V. NeugebauerAffiliated withDepartment of Neuroscience and Cell Biology, The University of Texas Medical Branch

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Abstract

Glutamate acts through a variety of receptors to modulate neurotransmission and neuronal excitability. Glutamate plays a critical role in neuroplasticity as well as in nervous system dysfunctions and disorders. Hyperfunction or dysfunction of glutamatergic neurotransmission also represents a key mechanism of pain-related plastic changes in the central and peripheral nervous system. This chapter will review the classification of glutamate receptors and their role in peripheral and central nociceptive processing. Evidence from preclinical pain models and clinical studies for the therapeutic value of certain glutamate receptor ligands will be discussed.

Keywords

Ionotropic glutamate receptors NMDA and non-NMDA receptor antagonists Metabotropic glutamate receptors Neurotransmission Nociception Plasticity Analgesia Preclinical Clinical