Transactions on Computational Systems Biology I

Volume 3380 of the series Lecture Notes in Computer Science pp 44-49

Genome Size and Numbers of Biological Functions

  • Ernest FeytmansAffiliated withSwiss Institute of Bioinformatics
  • , Denis NobleAffiliated withUniversity Laboratory of Physiology
  • , Manuel C. PeitschAffiliated withNovartis Institutes for Biomedical Research

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Calculations of potential numbers of interactions between gene products to generate physiological functions show that we can expect a highly non-linear relation between genome size and functional complexity. Moreover, very small differences in gene numbers or sequence can translate into very large differences in functionality.