Advances in Unconventional Computing

Volume 23 of the series Emergence, Complexity and Computation pp 1-28


Implementing Molecular Logic Gates, Circuits, and Cascades Using DNAzymes

  • Matthew R. LakinAffiliated withUniversity of New Mexico Email author 
  • , Milan N. StojanovicAffiliated withColumbia University
  • , Darko StefanovicAffiliated withUniversity of New Mexico

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The programmable nature of DNA chemistry makes it an attractive framework for the implementation of unconventional computing systems. Our early work in this area was among the first to use oligonucleotide-based logic gates to perform computations in a bulk solution. In this chapter we chart the development of this technology over the course of almost 15 years. We review our work on the implementation of DNA-based logic gates and circuits, which we have used to demonstrate digital logic circuits, autonomous game-playing automata, trainable systems and, more recently, decision-making circuits with potential diagnostic applications.