Chapter

Arterial Chemoreceptors in Physiology and Pathophysiology

Volume 860 of the series Advances in Experimental Medicine and Biology pp 379-385

The Carotid Body Does Not Mediate the Acute Ventilatory Effects of Leptin

  • E. OleaAffiliated withDepartment of Biochemistry, Molecular Biology and Physiology, Medicine School, University of Valladolid and IBGM/CSICCIBERES. Instituto de Salud Carlos III Email author 
  • , M. J. RibeiroAffiliated withChronic Diseases Research Center (CEDOC), Nova Medical School Faculdade Ciências Médicas, University of Nova Lisboa
  • , T. Gallego-MartinAffiliated withDepartment of Biochemistry, Molecular Biology and Physiology, Medicine School, University of Valladolid and IBGM/CSICCIBERES. Instituto de Salud Carlos III
  • , S. YuberoAffiliated withDepartment of Biochemistry, Molecular Biology and Physiology, Medicine School, University of Valladolid and IBGM/CSICCIBERES. Instituto de Salud Carlos III
  • , R. RigualAffiliated withDepartment of Biochemistry, Molecular Biology and Physiology, Medicine School, University of Valladolid and IBGM/CSICCIBERES. Instituto de Salud Carlos III
  • , J. F. MasaAffiliated withCIBERES. Instituto de Salud Carlos IIIPulmonary Division, Hospital San Pedro de Alcántara
  • , A. ObesoAffiliated withDepartment of Biochemistry, Molecular Biology and Physiology, Medicine School, University of Valladolid and IBGM/CSICCIBERES. Instituto de Salud Carlos III
  • , S. V. CondeAffiliated withChronic Diseases Research Center (CEDOC), Nova Medical School Faculdade Ciências Médicas, University of Nova Lisboa
  • , C. GonzalezAffiliated withDepartment of Biochemistry, Molecular Biology and Physiology, Medicine School, University of Valladolid and IBGM/CSICCIBERES. Instituto de Salud Carlos III

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Abstract

Leptin is a hormone produced mostly in adipose tissue and playing a key role in the control of feeding and energy expenditure aiming to maintain a balance between food intake and metabolic activity. In recent years, it has been described that leptin might also contributes to control ventilation as the administration of the hormone reverses the hypoxia and hypercapnia commonly encountered in ob/ob mice which show absence of the functional hormone. In addition, it has been shown that the carotid body (CB) of the rat expresses leptin as well as the functional leptin-B receptor. Therefore, the possibility exists that the ventilatory effects of leptin are mediated by the CB chemoreceptors. In the experiments described below we confirm the stimulatory effect of leptin on ventilation, finding additionally that the CB does not mediate the instant to instant control of ventilation.

Keywords

Leptin Carotid body Ventilation Catecholamine hypoxia