Chapter

Pathophysiology of Headaches

Part of the series Headache pp 31-66

Animal Models of Migraine

  • Anna P. AndreouAffiliated withHeadache Research – Section of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus Email author 
  • , Michael L. OshinskyAffiliated withNational Institute of Neurological Disorders and Stroke, National Institutes of Health

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Abstract

The headache research field is privileged to have in its preclinical laboratories well-established animal models that significantly facilitate and improve our understanding of headache mechanisms, in particular in terms of the molecular signalling and brain networks involved. A variety of pharmacological screening approaches for novel therapeutics and for the improvement of advanced pharmacological agents can be achieved in translational research utilising these models. The available migraine models have been developed based on our understanding of migraine from clinical, migraine patient-specific evidence. These clinical phenotypes have been successfully employed to model features of the disease physiology in animals and to provide reproducible meaningful physiological measures in the laboratory.