Chapter

Mammalian Transient Receptor Potential (TRP) Cation Channels

Volume 223 of the series Handbook of Experimental Pharmacology pp 873-897

Date:

TRPs and Pain

  • Jane E. SextonAffiliated withMolecular Nociception Group, Wolfson Institute for Biomedical Research, University College London Email author 
  • , Jeffrey VernonAffiliated withMolecular Nociception Group, Wolfson Institute for Biomedical Research, University College London
  • , John N. WoodAffiliated withMolecular Nociception Group, Wolfson Institute for Biomedical Research, University College London

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Abstract

Pain usually occurs as a result of tissue damage and has a role in healing and protection. However, in certain conditions it has no functional purpose and can become chronic and debilitating. A demand for more effective treatments to deal with this highly prevalent problem requires a better understanding of the underlying mechanisms. TRP channels are associated with numerous sensory functions across a wide range of species. Investigation into the expression patterns, electrophysiological properties and the effects of channel deletion in transgenic animal models have produced a great deal of evidence linking these channels to transduction of noxious stimuli as well as signalling within the pain system.

Keywords

TRP channels Pain Nociception Inflammation Neuropathy Analgesia