Chapter

Mammalian Transient Receptor Potential (TRP) Cation Channels

Volume 223 of the series Handbook of Experimental Pharmacology pp 1005-1034

Date:

Physiological Functions and Regulation of TRPC Channels

  • Hwei Ling OngAffiliated withSecretory Physiology Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health
  • , Lorena B. de SouzaAffiliated withSecretory Physiology Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health
  • , Kwong Tai ChengAffiliated withSecretory Physiology Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health
  • , Indu S. AmbudkarAffiliated withSecretory Physiology Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health Email author 

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Abstract

The TRP-canonical (TRPC) subfamily, which consists of seven members (TRPC1–TRPC7), are Ca2+-permeable cation channels that are activated in response to receptor-mediated PIP2 hydrolysis via store-dependent and store-independent mechanisms. These channels are involved in a variety of physiological functions in different cell types and tissues. Of these, TRPC6 has been linked to a channelopathy resulting in human disease. Two key players of the store-dependent regulatory pathway, STIM1 and Orai1, interact with some TRPC channels to gate and regulate channel activity. The Ca2+ influx mediated by TRPC channels generates distinct intracellular Ca2+ signals that regulate downstream signaling events and consequent cell functions. This requires localization of TRPC channels in specific plasma membrane microdomains and precise regulation of channel function which is coordinated by various scaffolding, trafficking, and regulatory proteins.

Keywords

TRPC channels Ca2+ signaling Protein complex Trafficking Regulation Function