Chapter

Metallointercalators

pp 373-388

Date:

Development of Metal Complexes as Potential Antimicrobials

  • Albert BolhuisAffiliated withDepartment of Pharmacy and Pharmacology, University of Bath Email author 
  • , Adair D. Richards

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Abstract

In 1969, the Surgeon General of the USA said that it was time “to close the book on infectious diseases” on the basis of the prolific success of antibiotics in the previous quarter century that had been widely prescribed [1]. This optimism, whilst seemingly justified at the time, was seriously misjudged, as the intervening 40 years have clearly demonstrated. This is because of the previously disregarded ability of bacteria to genetically mutate to an extent where future generations of bacteria proved immune to the effects of specific antibiotics – hence the need for novel approaches to combating microbial infections is as great as ever.