2008, pp 87-105

COPI: mechanisms and transport roles

Download Book (10,321 KB) As a courtesy to our readers the eBook is provided DRM-free. However, please note that Springer uses effective methods and state-of-the art technology to detect, stop, and prosecute illegal sharing to safeguard our authors’ interests.
Download Chapter (231 KB)


Coat protein I (COPI) is considered one of the best characterized coat complexes, which represent the core machinery by which vesicle formation and cargo sorting are coupled to initiate vesicular transport (Bonifacino and Lippincott-Schwartz 2003; McMahon and Mills 2004). Our understanding of the molecular mechanisms by which COPI acts and the transport path- ways in which it operates has evolved significantly over the years, and with considerable accompanying controversy. These aspects of COPI research will be reviewed. See also Fig. 1 for a timeline that summarizes its key discoveries.