Role of statins in cerebral vasospasm

Conference paper

DOI: 10.1007/978-3-211-75718-5_59

Volume 104 of the book series Acta Neurochirurgica Supplementum (NEUROCHIRURGICA)
Cite this paper as:
Sugawara T., Ayer R., Zhang J.H. (2008) Role of statins in cerebral vasospasm. In: Kırış T., Zhang J.H. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplementum, vol 104. Springer, Vienna

Abstract

3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, commonly known as statins, are widely used clinically for their lipid lowering properties. Recent evidence shows that statins are also effective in ameliorating cerebral vasospasm, which occurs as sequelae of subarachnoid haemorrhage. This review focuses on the pleiotropic effects of statins, and the putative mechanisms involved in statin mediated attenuation of cerebral vasospasm.

Keywords

Cerebral vasospasm subarachnoid haemorrhage statin pleiotropic effects Akt Rho eNOS 

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Division of NeurosurgeryLomaLinda University Medical CentreLoma LindaUSA
  2. 2.Department of Physiology and PharmacologyLoma Linda University Medical SchoolLoma LindaUSA