Cerebral Vasospasm pp 287-290
Role of statins in cerebral vasospasm
- Cite this paper as:
- Sugawara T., Ayer R., Zhang J.H. (2008) Role of statins in cerebral vasospasm. In: Kırış T., Zhang J.H. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplementum, vol 104. Springer, Vienna
3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, commonly known as statins, are widely used clinically for their lipid lowering properties. Recent evidence shows that statins are also effective in ameliorating cerebral vasospasm, which occurs as sequelae of subarachnoid haemorrhage. This review focuses on the pleiotropic effects of statins, and the putative mechanisms involved in statin mediated attenuation of cerebral vasospasm.
KeywordsCerebral vasospasm subarachnoid haemorrhage statin pleiotropic effects Akt Rho eNOS
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