Chapter

Neuropsychiatric Disorders An Integrative Approach

Volume 72 of the series Journal of Neural Transmission. Supplementa pp 311-315

Association of Parkinson’s disease with symptoms of attention deficit hyperactivity disorder in childhood

  • S. WalitzaAffiliated withDepartment of Child and Adolescent Psychiatry and Psychotherapy, University of Würzburg
  • , S. MelfsenAffiliated withDepartment of Child and Adolescent Psychiatry and Psychotherapy, University of Würzburg
  • , G. HerhausAffiliated withDepartment of Child and Adolescent Psychiatry and Psychotherapy, University of Würzburg
  • , P. ScheuerpflugAffiliated withDepartment of Child and Adolescent Psychiatry and Psychotherapy, University of Würzburg
  • , A. WarnkeAffiliated withDepartment of Child and Adolescent Psychiatry and Psychotherapy, University of Würzburg
  • , T. MüllerAffiliated withDepartment of Neurology, St. Josef Hospital, Ruhr University Bochum
  • , K. W. LangeAffiliated withDepartment of Experimental Psychology, University of Regensburg
  • , M. GerlachAffiliated withKlinik für Kinder- und Jugendpsychiatrie und Psychotherapie, Universität WürzburgDepartment of Child and Adolescent Psychiatry and Psychotherapy, University of Würzburg

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Abstract

Methylphenidate (MPH) is a centrally acting (psycho)stimulant which reversibly blocks the dopamine re-uptake transporter. At present MPH is one of the most frequently prescribed drugs for the symptomatic treatment of attention deficit hyperactivity disorder (ADHD). Although MPH has been in use for about 50 years, there is no information available concerning the long-term benefits and risks of medication. Based on experiments in rats it has been suggested that MPH treatment may affect the maturation of central dopaminergic systems and may be a risk factor for the development of Parkinson’s disease (PD). The aim of the present case-control study was to gain information about (1) ADHD-like symptoms that may precede PD motor symptoms, and (2) the exposure to psychostimulants in childhood. We used a German short version of the Wender Utah Rating Scale (WURS-k, Retz-Junginger et al., 2002) which is a reliable measure for the retrospective diagnosis of childhood ADHD, and another questionnaire including a rating scale for symptoms of ADHD in childhood (Q-ADHD-Child) according to DSM-IV and ICD-10 criteria.

Keywords

Parkinson’s disease depression attention deficit hyperactivity disorder methylphenidate stimulants cognitive deficits