Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae?
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An abnormally frequent atypical levodopa-unresponsive, akinetic-rigid syndrome with some similarity to PSP was identified in the Caribbean island Guadeloupe, and was associated with the consumption of plants of the Annonacea family, especially Annona muricata (corossol, soursop) suggesting a possible toxic etiology. Annonaceae contain two groups of potential toxins, alkaloids and acetogenins. Both alkaloids and annonacin, the most abundant acetogenin, were toxic in vitro to dopaminergic and other neurons. However we have focused our work on annonacin for two reasons: (1) annonacin was toxic in nanomolar concentrations, whereas micromolar concentrations of the alkaloids were needed, (2) acetogenins are potent mitochondrial poisons, like other parkinsonism-inducing compounds. We have also shown that high concentrations of annonacin are present in the fruit or aqueous extracts of the leaves of A. muricata, can cross the blood brain barrier since it was detected in brain parenchyma of rats treated chronically with the molecule, and induced neurodegeneration of basal ganglia in these animals, similar to that observed in atypical parkinsonism. These studies reinforce the concept that consumption of Annonaceae may contribute to the pathogenesis of atypical parkinsonism in Guadeloupe.
- Angibaud G, Gaultier C, Rascol O (2004) Atypical parkinsonism and Annonaceae consumption in New Caledonia. Mov Disord 19: 603–604 CrossRef
- Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT (2000) Chronic systemic pesticide exposure reproduces features of Parkinson’s disease. Nat Neurosci 3:1301–1006 CrossRef
- Caparros-Lefebvre D, Elbaz A and the Carribean Parkinsonism Study Group (1999) Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case control study. Lancet 354: 281–286 CrossRef
- Caparros-Lefebvre D, Sergeant N, Lees A, Camuzat A, Daniel S, Lannuzel A, Brice A, Tolosa E, Delacourte A, Duyckaerts C (2002) Guadeloupean Parkinsonism: a cluster of progressive supranuclear palsy-like taupathy. Brain 125: 801–811 CrossRef
- Champy P, Höglinger G, Feger J, Gleye C, Hocquemiller R, Laurens A, Guérineau V, Laprévote O, Medja F, Lombès A, Michel PP, Lannuzel A, Hirsch E, Ruberg M (2004) Acetogenin a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical Parkinsonism in Guadeloupe. J Neurochem 88:63–69 CrossRef
- Champy P, Melot A, Guérineau V, Gleye C, Fall D, Höglinger G, Ruberg M, Lannuzel A, Laprévote O, Laurens A, Hocquemiller R (2005) Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in Guadeloupe. Mov Disord 20: 1629–1633 CrossRef
- Hoglinger GU, Michel PP, Champy P, Feger J, Hirsch EC, Ruberg M, Lannuzel A (2005) Experimental evidence for a toxic etiology of tropical parkinsonism. Mov Disord 20: 118–119 CrossRef
- Langston JW, Forno LS, Tetrud J, Reeves AG, Kaplan JA, Karluk D (1999) Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann Neurol 46:598–605 CrossRef
- Lannuzel A, Michel PP, Caparros-Lefebvre D, Abaul J, Hocquemiller R, Ruberg M (2002) Toxicity of Annonaceae for dopaminergic neurons: potential role in atypical parkinsonism in Guadeloupe. Mov Disord 17: 84–90 CrossRef
- Lannuzel A, Michel PP, Höglinger GU, Champy P, Jousset A, Medja F, Lombés A, Darios F, Gleye C, Laurens A, Hocquemiller R, Hirsch EC, Ruberg M (2003) The mitochondrial complex I inhibitor annonacin is toxic to mesencephalic neurons by impairment of energy metabolism. Neuroscience 121: 287–296 CrossRef
- Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae?
- Book Title
- Parkinson’s Disease and Related Disorders
- Book Part
- pp 153-157
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- Series Title
- Journal of Neural Transmission. Supplementa
- Series Volume
- Springer Vienna
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- Editor Affiliations
- 1. Klinik und Poliklinik für Psychiatrie und Psychotherapie
- 2. Universitätsklinikum der TU Dresden
- 3. Israel Institute of Technology
- Author Affiliations
- 4. Department of Neurology, University Hospital, Pointe-à-Pitre, Guadeloupe
- 5. INSERM 679, Hôpital de la Salpêtrière, Paris
- 6. CNRS UMR 8076, France
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