Chapter

Cardiovascular Medicine

pp 2693-2720

Cardiovascular Complications of Obesity and the Metabolic Syndrome

  • Paul PoirierAffiliated withDepartment of Cardiology, Quebec Heart Institute/Laval University Faculty of Pharmacy
  • , Robert H. EckelAffiliated withDivision of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver and Health Sciences Center

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Abstract

  • At any given level of effort, the cardiac workload is greater in obese subjects.

  • Left ventricular hypertrophy occurs with morbid obesity and may be associated with left ventricular diastolic dysfunction.

  • With increasing rates of obesity, type 2 diabetes and the metabolic syndrome are seen in childhood.

  • The metabolic syndrome and inflammation are associated.

  • Genetic factors play an important role in obesity.

  • Obesity is strongly associated with systemic arterial hypertension.

  • There is an increased stroke risk with obesity.

  • Obesity is strongly associated with systemic arterial hypertension.

  • Morbid obesity is an independent risk factor for death after pulmonary embolism.

  • Obesity is a classical cause of alveolar hypoventilation.