This chapter will discuss the role of folate nutrition in the unique environment of human skin. The folates are a family of structurally similar, water-soluble, B vitamins, which have been well documented as vital in promoting human health and preventing disease. Optimized folate nutrient levels support many biochemical processes important for the maintenance and function of healthy skin. This importance is underscored by potential links between folate deficiency and psoriasis, vitiligo, exfoliative dermatitis, glossitis, and skin cancers. Human skin is particularly prone to the development of carcinomas. It is established that skin cancer risk correlates with exposure to the complete carcinogen, ultraviolet radiation (UVR) from sunlight. Total avoidance of solar exposure is impractical.