Prognostic Factors for Localized Renal Cell Carcinoma

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Abstract

Although surgical treatment is often curative for localized renal cell carcinoma (RCC), about 20–30% of those with localized disease at presentation will recur after initial treatment. Many clinical, histologic, and molecular factors have been identified that place patients with localized RCC at greater risk for recurrence or death. In this chapter, factors affecting RCC prognosis in patients with localized disease, including patient and tumor characteristics, as well as integrated prognostic algorithms developed for use prior to or after nephrectomy are reviewed. These prognostic tools allow for more accurate counseling of patients regarding their likely clinical course, help to classify patients with greatest potential to benefit from adjuvant treatments, and facilitate ongoing cancer surveillance.