PDGF Receptor and its Antagonists: Role in Treatment of PAH

Conference paper

DOI: 10.1007/978-1-60761-500-2_28

Volume 661 of the book series Advances in Experimental Medicine and Biology
Cite this paper as:
Grimminger F., Schermuly R.T. (2010) PDGF Receptor and its Antagonists: Role in Treatment of PAH. In: Yuan JJ., Ward J. (eds) Membrane Receptors, Channels and Transporters in Pulmonary Circulation. Advances in Experimental Medicine and Biology, vol 661. Humana Press, Totowa, NJ

Abstract

Pulmonary Hypertension is a severe lung disease, which is characterized by vasoconstriction and remodelling of the vessel wall. Mostly addressing the increased vascular tone, prostacyclin and its analogues, endothelin-receptor antagonists and phosphodiesterase type 5 inhibitors have been approved for treatment of PAH and represent the current therapeutic options. Mechanistically, these vasodilators decrease pulmonary vascular resistance and reduce thereby shear stress, which is a strong proliferative stimulus per se. Beside the development of new vasodilators, current research focuses on the development of causal treatment regimens aiming a normalization of the vessel structure. Mechanistically, increased proliferation, migration and a resistance to apoptosis of vascular cells represent key events in disease progression. In this context, tyrosine kinase inhibitors like imatinib have been shown to possess reverse remodelling potential in preclinical models of pulmonary hypertension by inducing apoptosis and blocking proliferation. This book chapter describes the role of the platelet derived growth factor (PDGF) receptor and its antagonists for treatment of pulmonary hypertension.

Keywords

Pulmonary hypertension tyrosine kinase PDGF proliferation growth factor 

Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.University Hospital, Medical Clinic II/VGiessenGermany
  2. 2.Department of Lung Development and RemodelingMax-Planck-Institute for Heart and Lung ResearchBad NauheimGermany