Life Extension in the Short-Lived Fish Nothobranchius furzeri
- Alessandro CellerinoAffiliated withFritz-Lipmann Institute for Age Research Email author
Short life span correlates with explosive growth and accelerated sexual maturation.
Short life span is correlated with the expression of age-related behavioral and histological changes.
Life span and expression of age-related markers can be modulated by water temperature.
Resveratrol, a drug characterized by its life-extending action in Caenorhabditis elegans and Drosophila, increases life span and retards expression of age-related markers.
Aging-related genes can be easily isolated by homology cloning.
Different populations or species of Nothobranchius show large-scale differences in captive life span.
In the last 3 years, N. furzeri has moved from a biological curiosity to a promising model system for drug validation. Furthermore, this species occupies a favorable position in the phylogeny of teleosts. It is close to the Japanese medaka, the puffer fishes, and the sticklebacks, and may represent a useful model for the comparative genomics of aging.
KeywordsNothobranchius furzeri resveratrol life span aging
- Life Extension in the Short-Lived Fish Nothobranchius furzeri
- Book Title
- Life-Span Extension
- Book Subtitle
- Single-Cell Organisms to Man
- pp 157-171
- Print ISBN
- Online ISBN
- Series Title
- Aging Medicine
- Humana Press
- Copyright Holder
- Humana Press, a part of Springer Science+Business Media, LLC
- Additional Links
- Nothobranchius furzeri
- life span
- Industry Sectors
- eBook Packages
- Editor Affiliations
- ID1. College of Medicine, Drexel University
- ID2. College of Medicine, Drexel University
- ID3. School of Medicine & Health Sciences, University of North Dakota
- Author Affiliations
- 1. Fritz-Lipmann Institute for Age Research, Beutenbergstr.11, Jena, Germany
To view the rest of this content please follow the download PDF link above.