Type 2 Diabetes, Pre-Diabetes, and the Metabolic Syndrome

Part of the series Current Clinical Practice pp 267-280


The Pathophysiology and Metabolic Impact of Hyperglycemia

  • Ronald A. CodarioAffiliated withUniversity of Pennsylvania Health System Thomas Jefferson University Hospital

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Accelerated vascular injury and inflammation are intimately associated with the devastating complications of type-2 diabetes. This process is initiated and perpetuated by the pathophysiological consequences of the hyperglycemic state. The vascular devastation of hyperglycemia can occur by several mechanisms, impacting the vessel wall, monocyte derived macrophages, and vascular smooth muscle cells.s

Key Words

Hyperglycemia Vascular injury Inflammation Hyperglycemia Monocyte derived macrophages Vascular smooth muscle cells