Chapter

The Dopamine Receptors

Part of the series The Receptors pp 479-524

Date:

Dopamine Receptor Subtypes in Reward and Relapse

  • David W. SelfAffiliated withDepartment of Psychiatry, The Seay Center for Basic and Applied Research in Psychiatric Illness, University of Texas Southwestern Medical Center Email author 

Abstract

With the advent of subtype-selective ligands and dopamine receptor knockout mice, the last two decades have seen an explosion in research on the role of dopamine receptor subtypes in reward and relapse to drug-seeking behavior. This chapter represents a relatively comprehensive review of this literature, beginning with the ability of D1-like and D2-like receptor agonists to support self-administration behavior and produce conditioned preference, and followed by the modulation of natural reward, brain stimulation reward, and conditioned reward with subtype-selective ligands and dopamine receptor knockout mice. Subsequent sections describe the modulation of drug and alcohol self-administration by dopamine receptor subtypes, and role of dopamine receptor subtypes in relapse to drug and alcohol seeking in animal models. Finally, down-regulation in dopamine receptors following chronic drug self-administration is discussed in reference to differential changes in dopamine receptor-mediated behavior, suggesting that better integration between biological and behavioral data is needed in future studies.

Keywords

D1 D2 D1-like D2-like D3 D4 D5 Reinforcement Reinstatement Cocaine Amphetamine Heroin Nicotine Alcohol