Chapter

Proteomics of Human Body Fluids

pp 377-397

Proteomics of Human Pancreatic Juice

  • Mads GrønborgAffiliated withMcKusick-Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins UniversityDepartment of Biochemistry and Molecular Biology, University of Southern Denmark
  • , Anirban MaitraAffiliated withMcKusick-Nathans Institute of Genetic Medicine, The Sol Goldman Pancreatic Cancer Research Center, and Departments of Biological Chemistry, Pathology and Oncology, Johns Hopkins University
  • , Akhilesh PandeyAffiliated withMcKusick-Nathans Institute of Genetic Medicine, and Departments of Biological Chemistry, Oncology and Pathology, Johns Hopkins University

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Abstract

Pancreatic juice has recently been characterized in detail using proteomic methods. The cataloging of proteins from healthy individuals and those diagnosed with pancreatic cancer has revealed the presence of a number of proteins in pancreatic juice that could serve as potential biomarkers for cancer. Because obtaining pancreatic juice is not trivial, it is possible that these biomarkers can be detected in serum using more sensitive methods like ELISA. Here, we discuss the protein constituents of pancreatic juice with special reference to cancer biomarkers.

Key Words

Pancreatic juice LC-MS/MS quantitative proteomics biomarker discovery mass spectrometry