Intraperitoneal Cancer Therapy

Part of the series Current Clinical Oncology pp 71-100

Hyperthermia and Chemotherapy: The Science

  • Roger A. VertreesAffiliated withUniversity of Texas Medical Branch
  • , Jeffrey M. JordanAffiliated withJames W. McLaughlin Fellow, University of Texas Medical Branch
  • , Joseph B. ZwischenbergerAffiliated withDepartment of Surgery, Medicine, and Radiology, University of Texas Medical Branch

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Cancer ranks second only to heart disease as the greatest cause of mortality in the United States. Despite significant strides in diagnosis and therapeutics, clinical treatment of metastatic cancer still yields a poor prognosis. Basic science research is increasing our knowledge of the mechanisms by which chemotherapeutic and hyperthermic modalities exert their antitumor activity. Herein, we describe the current state of knowledge of these treatment modalities and the basic science behind their clinical usefulness. Moreover, we identify gaps in our understanding of the basic science of these treatments. Basic science is primed to exert a substantial role in extending our therapeutic options through the clarification of current therapeutic mechanisms, as well as the generation of novel treatments.

Key Words

Cancer neoplasia metastasis chemotherapy hyperthermia