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Streptogramins are a naturally occurring class of antibiotics originally isolated from Streptomyces pristinaspiralis (6). This family includes many related antibiotics including pristanamycins, ostreomycins, mikamycins, and virginiamycins (25). In Europe, pristinamycin was commercially available as an oral antistaphylococcal agent; however, owing to poor water solubility, an injectable product was not available until 1999. Therefore, clinical experience with pristinamycin has been limited to non-life-threatening infections.