Chapter

Systems Biology of RNA Binding Proteins

Volume 825 of the series Advances in Experimental Medicine and Biology pp 1-55

Date:

Evolutionary Conservation and Expression of Human RNA-Binding Proteins and Their Role in Human Genetic Disease

  • Stefanie GerstbergerAffiliated withHoward Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University
  • , Markus HafnerAffiliated withLaboratory of Muscle Stem Cells and Gene Regulation, NIH National Institute of Arthritis and Musculoskeletal and Skin Disease
  • , Manuel AscanoAffiliated withHoward Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University
  • , Thomas TuschlAffiliated withHoward Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University Email author 

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Abstract

RNA-binding proteins (RBPs) are effectors and regulators of posttranscriptional gene regulation (PTGR). RBPs regulate stability, maturation, and turnover of all RNAs, often binding thousands of targets at many sites. The importance of RBPs is underscored by their dysregulation or mutations causing a variety of developmental and neurological diseases. This chapter globally discusses human RBPs and provides a brief introduction to their identification and RNA targets. We review RBPs based on common structural RNA-binding domains, study their evolutionary conservation and expression, and summarize disease associations of different RBP classes.

Keywords

RNA-binding domains, overview RNA-binding proteins, tissue specificity RNA-binding proteins, abundance RNA-binding proteins, genetic diseases