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Molecular Biology of Phleboviruses

  • Chapter
The Bunyaviridae

Part of the book series: The Viruses ((VIRS))

Abstract

The Phlebovirus genus encompasses two groups of viruses, the phlebotomus or sandfly fever group (PHL) and the Uukuniemi group (Calisher, 1991). In a previous taxonomic organization the two groups, based on serological relationships, were considered as different genera in the Bunyaviridae family, but because of the similarities in biochemical properties and in genome organization and expression, the two groups were combined into one genus, Phlebovirus. However, the biological properties of the two groups are distinct: the phlebotomus fever viruses are transmitted by sandflies and gnats whereas the uukuviruses are transmitted by ticks (Bishop and Shope, 1979). Several PHL viruses, but none of the uukuviruses, have been associated with disease in humans, although antibodies to Uukuniemi virus have been detected in humans (Tesh, 1988; Beaty and Calisher, 1991). This chapter focuses on phlebovirus genome organization and expression, and the data obtained in the past few years will be discussed to provide an update on earlier reviews (Elliott, 1990; Bouloy, 1991; Elliott et al., 1991). The Phlebovirus genus is composed of at least 51 different viruses (39 within the sandfly fever group and 12 within the Uukuniemi group; Calisher, 1991; see Chapter 1), but the information on the molecular biology of these viruses comes from the analysis of only a few of them, namely Punta Toro (PT), Rift Valley fever (RVF), sandfly fever Sicilian (SFS), Toscana (TOS), and Uukuniemi (UUK) viruses.

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  1. Laboratory of Virology, Istituto Superiore di Sanità, 00161, Rome, Italy

    Colomba Giorgi

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  1. Colomba Giorgi
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  1. Institute of Virology, University of Glasgow, Glasgow, Scotland

    Richard M. Elliott

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© 1996 Springer Science+Business Media New York

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Giorgi, C. (1996). Molecular Biology of Phleboviruses. In: Elliott, R.M. (eds) The Bunyaviridae. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1364-7_5

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  • DOI: https://doi.org/10.1007/978-1-4899-1364-7_5

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