Chapter

Cellular Peptidases in Immune Functions and Diseases

Volume 421 of the series Advances in Experimental Medicine and Biology pp 127-140

CD26/Dipeptidyl Peptidase IV in Lymphocyte Growth Regulation

  • Siegfried AnsorgeAffiliated withInstitute of Experimental Internal Medicine Department of Internal Medicine, Otto-von-Guericke-University
  • , Frank BühlingAffiliated withInstitute of Experimental Internal Medicine Department of Internal Medicine, Otto-von-Guericke-University
  • , Thilo KähneAffiliated withInstitute of Experimental Internal Medicine Department of Internal Medicine, Otto-von-Guericke-University
  • , Uwe LendeckelAffiliated withInstitute of Experimental Internal Medicine Department of Internal Medicine, Otto-von-Guericke-University
  • , Dirk ReinholdAffiliated withInstitute of Experimental Internal Medicine Department of Internal Medicine, Otto-von-Guericke-University
  • , Michael TägerAffiliated withInstitute of Experimental Internal Medicine Department of Internal Medicine, Otto-von-Guericke-University
  • , Sabine WrengerAffiliated withInstitute of Experimental Internal Medicine Department of Internal Medicine, Otto-von-Guericke-University

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Abstract

T lymphocyte activation is controlled by the T cell antigen receptor-CD3 complex and a number of accessory molecules on the surface of lymphocytes which are triggered by special ligands outside of the cell. During the last years, there has been a considerable progress in the identification of these accessory structures and the mechanisms of their actions.