Chapter

Molecular Aspects of Development and Aging of the Nervous System

Volume 265 of the series Advances in Experimental Medicine and Biology pp 41-52

Regulation of the Glial Fibrillary Acidic Protein (GFAP) and of its Encoding mRNA in the Developing Brain and in Cultured Astrocytes

  • M. TardyAffiliated withINSERM U-282 Hôpital Henri Mondor
  • , C. FagesAffiliated withINSERM U-282 Hôpital Henri Mondor
  • , G. Le PrinceAffiliated withINSERM U-282 Hôpital Henri Mondor
  • , B. RollandAffiliated withINSERM U-282 Hôpital Henri Mondor
  • , J. NunezAffiliated withINSERM U-282 Hôpital Henri Mondor

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Abstract

The Glial Fibrillary Acidic Proctein (GFAP) is the monomer of a well characterized type of intermediary filaments, the fliofilaments, structurally identified as 10nm in diameter and which are essential components of the cytoskeletal architecture of the astrocyte (see Eng 1980 for a review). The expression of GFAP has been found to be highly specific of this cell type (Eng et al. 1971; Bignami et al. 1972; Uyeda et al. 1972; Gilden et al.1976: Ludwin et al. 1976; Ludwin et al. 1976; Lach and Weinmander 1978) and may therefore be used as an exclusive marker of astroglial cells.