Chapter

Vasopeptides

Volume 21 of the series Advances in Experimental Medicine and Biology pp 399-408

A Structure-Activity Basis for Vasotropic Peptide Therapy in Shock

  • Burton M. AlturaAffiliated withDepartments of Anesthesiology and Physiology, Albert Einstein College of Medicine
  • , S. G. HersheyAffiliated withDepartments of Anesthesiology and Physiology, Albert Einstein College of Medicine

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Abstract

Chemical analogues which enhance one or several biologic properties of important naturally occurring substances are regularly sought. Currently in this regard, there is intense interest in developing such analogues of the neurohypophyseal hormones (NHPH), oxytocin and vasopressin. Several which have recently been synthesized not only offer the possibility of increased insight into structure-activity relationships but also may provide for more precise therapeutic drug actions (17).