Modelling and Measurements of Light Propagation in Tissue for Diagnostic and Therapeutic Applications

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Abstract

The propagation of light (ultraviolet, visible and infrared) in tissue is fundamental to many diagnostic and therapeutic applications in photomedicine. The former are based on the effect of tissues on light, as in, for example, diffuse transmittance or reflectance spectroscopy, and fluorescence spectroscopy. Therapeutic applications, which depend on the effect of light on tissue involve the absorption of light energy by tissue chromophores, leading to specific or non-specific photophysical/photochemical changes. In both cases, the spatial (and temporal) distribution of light fluence is important, and is determined essentially by the optical properties of the tissue.