Human Neutrophil Granule Cationic Protein CAP37 is a Specific Macrophage Chemotaxin that Shares Homology with Inflammatory Proteinases
- John G. MorganAffiliated withGenelabs Inc.
- , H. Anne PereiraAffiliated withDept. of Microbiology and Immunology, Emory University School of Medicine
- , Teresa SukiennickiAffiliated withGenelabs Inc.
- , John K. SpitznagelAffiliated withDept. of Microbiology and Immunology, Emory University School of Medicine
- , James W. LarrickAffiliated withGenelabs Inc.
Cationic antimicrobial protein CAP37 (Mr = 37 kD) is derived from the azurophilic granules of human PMN. In vitro and in vivo studies demonstrate that CAP37 is a novel monocyte-specific chemoattractant. The N-terminal amino acid sequence of CAP37 shares significant homology with a number of inflammatory molecules with protease activity including elastase and cathepsin G. However, substitutions in the catalytic triad (serine for a histidine at position 41 and glycine for a serine at position 175), may account for its lack of serine protease activity. A full length cDNA for CAP37 was identified in an HL60 cDNA library screened with oligonucleotide probes designed from the N-terminal amino acid sequence. Sequencing of the cDNA reveals a protein of 225 amino acids with significant nucleotide homology to cathepsin G and human neutrophil elastase.
- Human Neutrophil Granule Cationic Protein CAP37 is a Specific Macrophage Chemotaxin that Shares Homology with Inflammatory Proteinases
- Book Title
- Chemotactic Cytokines
- Book Subtitle
- Biology of the Inflammatory Peptide Supergene Family
- pp 89-96
- Print ISBN
- Online ISBN
- Series Title
- Advances in Experimental Medicine and Biology
- Series Volume
- Series ISSN
- Springer US
- Copyright Holder
- Plenum Press, New York
- Additional Links
- Industry Sectors
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- Editor Affiliations
- 1. The University of Bath
- 2. Sandoz Research Institute
- 3. University of Michigan
- Author Affiliations
- 4. Genelabs Inc., 505 Penobscot Drive, Redwood City, CA, 94063, USA
- 5. Dept. of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, 30322, USA
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