Chapter

Myoblast Transfer Therapy

Volume 280 of the series Advances in Experimental Medicine and Biology pp 147-158

Control of Satellite Cell Proliferation

  • Richard BischoffAffiliated withDepartment of Anatomy and Neurobiology, Washington University School of Medicine

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Abstract

Satellite cells are reserve stem cells of adult skeletal muscle and thus represent a potential source of myogenic cells to use in myoblast replacement therapy of neuromuscular disease. Optimal application of this strategy requires knowledge of factors that control the growth and differentiation of satellite cells. Control of satellite cell proliferation is a complex phenomenon determined by the contribution of both positive and negative factors (Fig. 1).