Molecular and Genetic Aspects of the Immune Responses to Hepatitis B Viral Antigens

  • David R. Milich
Conference paper

DOI: 10.1007/978-1-4684-5712-4_12

Volume 257 of the book series Advances in Experimental Medicine and Biology (AEMB)
Cite this paper as:
Milich D.R. (1989) Molecular and Genetic Aspects of the Immune Responses to Hepatitis B Viral Antigens. In: Askonas B.A., Moss B., Torrigiani G., Gorini S. (eds) The Immune Response to Viral Infections. Advances in Experimental Medicine and Biology, vol 257. Springer, Boston, MA

Summary

In the absence of an inbred animal model of hepatitis B virus (HBV) infection, several laboratories have chosen to study the murine immune response to HBV-encoded proteins as immunogens as opposed to an infectious agent. This article reviews the immunogenicity, the fine specificity of T and B cell recognition of HBV antigens, and the genetic influences that regulate these responses. It is anticipated that this approach will increase our understanding of immune-mediated viral clearance mechanisms during HBV infection, and may provide the framework for the design of second and third generation HBV vaccines.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • David R. Milich
    • 1
  1. 1.Department of Molecular BiologyResearch Institute of Scripps ClinicLa JollaUSA