The Immune Response to Viral Infections pp 115-133
Molecular and Genetic Aspects of the Immune Responses to Hepatitis B Viral Antigens
- Cite this paper as:
- Milich D.R. (1989) Molecular and Genetic Aspects of the Immune Responses to Hepatitis B Viral Antigens. In: Askonas B.A., Moss B., Torrigiani G., Gorini S. (eds) The Immune Response to Viral Infections. Advances in Experimental Medicine and Biology, vol 257. Springer, Boston, MA
In the absence of an inbred animal model of hepatitis B virus (HBV) infection, several laboratories have chosen to study the murine immune response to HBV-encoded proteins as immunogens as opposed to an infectious agent. This article reviews the immunogenicity, the fine specificity of T and B cell recognition of HBV antigens, and the genetic influences that regulate these responses. It is anticipated that this approach will increase our understanding of immune-mediated viral clearance mechanisms during HBV infection, and may provide the framework for the design of second and third generation HBV vaccines.
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