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Progress in Polyamine Research

Volume 250 of the series Advances in Experimental Medicine and Biology pp 667-674

The Role of Glutathionylspermidine and Trypanothione in Regulation of Intracellular Spermidine Levels During Growth of Crithidia Fasciculata

  • Alan H. FairlambAffiliated withDepartment of Medical Protozoology, London School of Hygiene and Tropical Medicine

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Abstract

Trypanosomatids are unusual in that a considerable proportion of their intracellular spermidine and glutathione (GSH) is found as the conjugate Ni-glutathionylspermidine (GSH-SPD) and N1-, N8-bis-(glutathionyl)spermidine (T[SH]2)1. The latter compound is unique to the parasitic and free-living Trypanosomatidae and has been assigned the trivial name trypano-thione2.