Chapter

Genetic Disorders and the Fetus

pp 31-52

Amniocentesis

  • Sherman EliasAffiliated withDepartment of Obstetrics and Gynecology, Division of Reproductive Genetics, The University of Tennessee College of Medicine
  • , Joe Leigh SimpsonAffiliated withDepartment of Obstetrics and Gynecology, Division of Reproductive Genetics, The University of Tennessee College of Medicine

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Amniocentesis is a surgical technique that has been used for a variety of indications. The procedure was first utilized in Germany in the early 1880s to treat polyhydramnios (Lambl, 1881; Schatz, 1882). In 1930, Menées et al. (1930) used amniocentesis to inject contrast media into the amniotic sac in order to evaluate the fetus and localize the placenta. The procedure of using amniocentesis to introduce hypertonic saline into the amniotic sac for pregnancy termination made its appearance in 1937 (Aburel, 1937). Amniocentesis utilization increased rapidly in the 1950s, when spectrophotometric analysis of bilirubin proved valuable in monitoring fetuses with Rh isoimmunization (Bevis, 1952; Walker, 1957).