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The Enzymes of Biological Membranes pp 315–347Cite as

Membrane-Bound γ-Glutamyl Transpeptidase

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Abstract

γ-Glutamyl transpeptidase is a membrane-bound enzyme that catalyzes the transfer of the γ-glutamyl moiety of glutathione (and of other γ-glutamyl compounds) to amino acid (and peptide) acceptors as indicated in reaction (1):

$$ glutathione + a\min o\,acid \to \gamma - glutamyl\,a\min o\,acid + cysteinyl\,glycine $$
((1))

This reaction is the first step in a quantitatively significant pathway of glutathione metabolism, and it has been postulated that this or analogous reactions are involved in amino acid transport. Thus, γ-glutamyl transpeptidase mediates the translocation of the amino acid across the cell membrane by interacting with both extracellular amino acid and intracellular glutathione (or other compounds that contain the γ-glutamyl carrier); according to this idea, the amino acid enters the cell as a γ-glutamyl amino acid.

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Authors and Affiliations

  1. Department of Biochemistry, Cornell University Medical College, New York, New York, 10021, USA

    Alton Meister & Suresh S. Tate

  2. Department of Anatomy, The Medical College of Pennsylvania, Philadelphia, Pennsylvania, 19129, USA

    Leonard L. Ross

Authors
  1. Alton Meister
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  2. Suresh S. Tate
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  3. Leonard L. Ross
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Editors and Affiliations

  1. Department of Biochemistry School of Medicine, Saint Louis University, USA

    Anthony Martonosi

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© 1976 Plenum Press, New York

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Meister, A., Tate, S.S., Ross, L.L. (1976). Membrane-Bound γ-Glutamyl Transpeptidase. In: Martonosi, A. (eds) The Enzymes of Biological Membranes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2658-8_13

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  • DOI: https://doi.org/10.1007/978-1-4684-2658-8_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2660-1

  • Online ISBN: 978-1-4684-2658-8

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