Myelin Basic Protein, the “Executive” Molecule of the Myelin Membrane

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Myelin basic protein (MBP) has been known since the mid 1960’s. Its primary structure was reported by two groups independently, Eylar et al. reported on the bovine MBP while Carnegie reported on the human MBP (Eylar et al., 1971; Carnegie, 1971). The molecular weight of this protein was computed to be 18500. It is devoid of cysteinyl residues, is highly basic (12 lysyl and 19 arginyl residues) and has 11 prolines, 3 of which occur as a triproline sequence.