Chemistry and Biology of Serpins

Volume 425 of the series Advances in Experimental Medicine and Biology pp 223-237

Structure-Function Studies on PEDF

A Noninhibitory Serpin with Neurotrophic Activity
  • S. Patricia BecerraAffiliated withLaboratory of Retinal Cell and Molecular Biology, National Eye Institute National Institutes of Health

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Pigment epithelium-derived factor (PEDF) is a neurotrophic factor. In vitro it induces neuronal differentiation of retinoblastoma cells and promotes survival of cerebellar granule cell neurons. By virtue of amino acid sequence homology PEDF is a unique serpin member.