Feline Aminopeptidase N is a Receptor for All Group I Coronaviruses
Purchase on Springer.com
$29.95 / €24.95 / £19.95*
* Final gross prices may vary according to local VAT.
Human coronavirus HCV-229E and porcine transmissible gastroenteritis virus (TGEV), both members of coronavirus group I, use aminopeptidase N (APN) as their cellular receptors. These viruses show marked species specificity in receptor utilization as they can only use APN of their respective species to initiate virus infection. Feline and canine coronaviruses are also group I coronaviruses. To determine whether feline APN could serve as a receptor for feline coronaviruses (FCoVs), we cloned the cDNA encoding feline APN (fAPN) by PCR from feline cells and stably expressed it in FCoV-resistant mouse or hamster cells. These became susceptible to infection with either of several biotypes of FCoVs. The expression of recombinant fAPN also made hamster and mouse cells susceptible to infection with other group I coronaviruses, including several canine coronavirus strains, transmissible gastroenteritis virus (TGEV), and human coronavirus HCV-229E. Thus, fAPN served as a functional receptor for each of these coronaviruses in group I. As expected, fAPN could not serve as a receptor for mouse hepatitis virus (MHV), a group II coronavirus which uses murine biliary glycoproteins as receptors. Thus, fAPN acts as a common receptor for coronaviruses in group I, in marked contrast to human and porcine APN glycoproteins which serve as receptors only for human and porcine coronaviruses, respectively. These observations suggest that cats could serve as a “mixing vessel” in which simultaneous infection with several group I coronaviruses could lead to recombination of viral genomes.
- Barlough, J. E., and Stoddart, C. A., 1990, Feline coronaviral infections, in: Infectious diseases of the dog and cat, (C. E. Greene, ed.), W. B. Saunders Co., Philadelphia, pp. 300–312.
- Barlough, J. E., Stoddart, C. A., Sorresso, G. P., Scott F. W., and Jacobson, R. H.,1984, Experimental inoculation of cats with canine coronavirus and subsequent challenge with feline infectious peritonitis virus, Lab. Anim. Sci. 34: 592–597.
- Barlough, J. E., Johnson-Lussenburg, C. M., Stoddart, C. A., Scott, F. W., and Jacobson, R. H., 1985, Experimental inoculation of cats with human coronavirus 229E and subsequent challenge with feline infectious peritonitis virus, Can. J. Comp. Med. 49: 303–307.
- Benbacer, L., Kut, E., Besnardeau, L., Laude, H., and Delmas, B., 1997, Interspecies aminopeptidase-N chimeras reveal species specific receptor recognition by CCV, FIPV, and TGEV, J. Virol. 71: 734–737.
- Delmas, B., Gelfi, J., L’Haridon, R., Vogel, L. K., Sjöström, H., Norén, O., and Laude, H., 1992, Aminopeptidase N is a major receptor for the enteropathogenic coronavirus TGEV, Nature (London) 357: 417–419. CrossRef
- Delmas, B., Gelfi, J., Kut, E., Sjöström, H., Norén, O., and Laude, H., 1994a, Determinants essential for the transmissible gastroenteritis virus-receptor interaction reside within a domain of aminopeptidase N that is distinct from the enzymatic site, J. Virol. 68: 5216–5224.
- Delmas, B., Gelfi, J., Sjöström, H., Norén, O., and Laude, H., 1994b, Further characterization of aminopeptidase N as a receptor for coronaviruses, Adv. Exp. Med. Biol. 342: 293–298. CrossRef
- Herrewegh, A. A. P. M., Vennema, H., Horzinek, M. C., Rottier, P. J. M., and de Groot, R. J., 1995, The molecular genetics of Feline coronaviruses: Comparative sequence analysis of the ORF7a/7b transcription unit of different biotypes, Virology 212: 622–631. CrossRef
- Holmes, K. V., and Dveksler, G. S., 1994, Specificity of coronavirus/receptor interactions, in: Cellular Receptors for Animal Viruses, (E. Wimmer, ed.), Cold Spring Harbor Laboratory Press, pp. 403–443.
- Holmes, K. V., and Compton, S. R., 1995, Coronavirus receptors, in: The Coronaviruses, (S. Siddell, ed.), Plenum Press, New York, pp. 55–72.
- Holmes, K. V., and Lai, M. M. C., 1996, Coronaviridae: The viruses and their replication, in: Virology (Fields), 3rd ed., (B. N. Fields, D. M. Knipe and P. M. Howley, eds.), Lippincott-Raven Publishers, Philadelphia, pp. 1075–1093.
- Kenny, A. J., and Maroux, S., 1982, Topology of microvillar membrane hydrolases of kidney and intestine, Physiol. Rev. 62:91–128.
- Kolb, A., Maile, J., Heister, A., and Siddell, S., 1996, Characterization of functional domains in the human coronavirus 229E receptor, J. Gen. Virol. 77: 2515–2521. CrossRef
- Kozak, M., 1987, An analysis of 5-noncoding sequences from 699 vertebrate messenger RNAs, Nucleic Acids Res 15:8125–8148. CrossRef
- Levis, R., Cardellichio, C. B., Scanga, C. A., Compton, S. R., and Holmes, K. V., 1995, Multiple receptor-dependent steps determine the species specificity of HCV-229E infection, Adv. Exp. Med. Biol. 380: 337–344. CrossRef
- Look, A. T., Ashmun, R. A., Shapiro, L. H., and Peiper, S. C, 1989, Human myeloid plasma membrane glycoprotein CD13 (gpl50) is identical to aminopeptidase N, J. Clin. Invest. 83: 1299–1307. CrossRef
- Pedersen, N. C., 1987, Virologie and immunologic aspects of feline infectious peritonitis virus infection, Adv. Exp. Med. Biol. 218: 529–550. CrossRef
- Pedersen, N. C., and Boyle, J. F., 1980, Immunologic phenomena in the effusive form of feline infectious peritonitis, Am. J. Vet. Res. 41: 868–876.
- Pedersen, N. C., Black, J. W., Boyle, J. F., Evermann, J. F., McKeirnan, A. J., and Ott, R. L., 1984, Pathogenic differences between various feline coronavirus isolates, Adv. Exp. Med. Biol. 173:337–344.
- Reynolds, D. J., and Garwes D. J., 1979, Virus isolation and serum antibody responses after infection of cats with transmissible gastroenteritis virus, Arch. Virol. 60:161–166. CrossRef
- Scott, F. W., 1986a, Feline infectious peritonitis and other feline coronaviruses, in: Current veterinary therapy IX, (R. W. Kirk, ed.), W. B. Saunders Co., Philadelphia, pp. 1059–1062.
- Scott, F. W., 1986b, Immunization against feline coronaviruses, Adv. Exp. Med. Biol. 218:569–576. CrossRef
- Tresnan, D. B., Levis, R., and Holmes, K. V., 1996, Feline aminopeptidase N (fAPN) serves as a receptor for feline, canine, porcine and human coronaviruses in serogroup I, J. Virol. 70:8669–8674
- Wege, H., Siddell, S., and ter Meulen, V., 1982, The Biology and Pathogenesis of Coronaviruses, Curr. Topics Microbiol. Immunol. 99: 165–200. CrossRef
- Wesseling, J. G., Vennema, H., Godeke, G. J., Horzinek, M. C., Rottier, P. J., 1994, Nucleotide sequence and expression of the spike (S) gene of canine Coronavirus and comparison with the S proteins of feline and porcine coronaviruses,J. Gen. Virol. 75: 1789–1794. CrossRef
- Yeager, C. L., Ashmun, R. A., Williams, R. K., Cardellichio, C. B., Shapiro, L. H., Look, A. T., and Holmes, K. V, 1992, Human aminopeptidase N is a receptor for human coronavirus 229E, Nature (London) 357: 420–422. CrossRef
- Feline Aminopeptidase N is a Receptor for All Group I Coronaviruses
- Book Title
- Coronaviruses and Arteriviruses
- pp 69-75
- Print ISBN
- Online ISBN
- Series Title
- Advances in Experimental Medicine and Biology
- Series Volume
- Series ISSN
- Springer US
- Copyright Holder
- Plenum Press, New York
- Additional Links
- Industry Sectors
- eBook Packages
- Editor Affiliations
- 1. National Center for Biotechnology, CSIC, Campus Universidad Autónoma
- 2. Institute of Virology, University of Würzburg
- 3. Institute of Medical Microbiology, State University of Leiden
- Author Affiliations
- 4. Department of Microbiology, University of Colorado Health Sciences Center, Denver, Colorado, 80262, USA
To view the rest of this content please follow the download PDF link above.