Enzymology and Molecular Biology of Carbonyl Metabolism 7

Volume 463 of the series Advances in Experimental Medicine and Biology pp 1-7

The Big Book of Aldehyde Dehydrogenase Sequences

An Overview of the Extended Family
  • John PerozichAffiliated withDepartment of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine
  • , Hugh NicholasAffiliated withPittsburgh Supercomputing Center, Carnegie-Mellon University
  • , Ronald LindahlAffiliated withDepartment of Biochemistry and Molecular Biology, University of South Dakota
  • , John HempelAffiliated withDepartment of Biological Sciences, University of Pittsburgh

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Traditionally, research on aldehyde dehydrogenases (ALDHs, EC 1.2.1) has focused on three groups: class 1, 2, and 3 ALDHs. Class 1 and 2 ALDHs are very closely related homotetramers and both participate in ethanol metabolism, though class 1 ALDHs can oxidize wide range of metabolites, including retinal (reviewed Lindahl, 1982; Yoshida et al., 1). Class 3 ALDHs appear at first glance to be highly divergent from the other 2 classes. Class 3 ALDHs share only about 25% sequence identity with class 1 and 2 ALDHs and are homodimers. However, in main-chain folding, the structures of the class 2 and 3 monomers are nearly identical (Hempel et al., 1999)