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Progress in Cell Cycle Research

Part of the series Progress in Cell Cycle Research pp 193-206

Circadian variation of cell proliferation and cell cycle protein expression in man: Clinical implications

  • Georg A. BjarnasonAffiliated withDivision of Medical Oncology, Toronto-Sunnybrook Regional Cancer CentreDepartment of Medicine, University of Toronto
  • , Richard JordanAffiliated withFaculty of Dentistry, University of TorontoDepartments of Laboratory Medicine and Dentistry, Sunnybrook and Women’s College Health Sciences Centre

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Abstract

Most physiological, biochemical and behavioural processes have been shown to vary in a regular and predictable periodic manner with respect to time. This review focuses on the circadian rhythm in cell proliferation in bone marrow and gut and how this is associated with a circadian expression of cell cycle proteins in human oral mucosa. The control of circadian rhythms by the suprachiasmatic nuclei and the evolving understanding of the genetic and molecular biology of the circadian clock is outlined. Finally, the potential clinical impact of chronobiology in cancer medicine is discussed.