Genetic Engineering

Volume 14 of the series Genetic Engineering pp 13-31

Complications of RNA Heterogeneity for the Engineering of Virus Vaccines and Antiviral Agents

  • Esteban DomingoAffiliated withCentro de Biología Molecular (CSIC-UAM), Universidad Autónoma de Madrid
  • , John J. HollandAffiliated withDepartment of Biology, 0116, University of California, San Diego

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The most abundant viruses infecting plants, animals and humans are the RNA viruses (riboviruses and retroviruses). These elemental life forms are hypervariable to a degree that is difficult to comprehend fully. The genetics of RNA viruses is a strange, unfamiliar, and often counterintuitive genetics.