Abstract
CD44, originally defined by antibodies as a leukocyte surface protein (reviewed in Haynes et al., 1989), has become a polymorphic family of proteins expressed in various cells and conditions. The polymorphism is due to differential modifications and to splice variation (Hughes et al., 1983; Omary et al., 1988; Kansas et al., 1989; Picker et al., 1989; Goldstein et al., 1989; Goldstein and Butcher, 1990; Stamenkovic et al., 1991, Dougherty et al., 1991; Brown et al., 1991; Günthert et al., 1991; Shtivelman and Bishop, 1991; Jackson et al., 1992). Because of the polymorphism a multitude of functions can be expected. Yet these need t be defined. All or part of the CD44 glycoproteins have affinity for hyaluronic acid, some forms are linked to chondoitin sulfate and bind fibronectin and collagen (Aruffo et al., 1990; Miyake et al., 1990; Stamenkovic et al., 1989; Goldstein et al., 1989; Wolffe et al. 1990; Carter and Wayner, 1988; Jalkanen and Jalkanen, 1992). These affinnites may have functions in association with different primary structures domains introduced by splice variation.
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Abbreviations
- CD44 :
-
Cluster Determinant-44;
- PCR :
-
Polymerase Chain Reaction;
- AP-1-γ:
-
Activating Protein 1 (the prototype is a heterodimer of fos and jun);
- CMV :
-
Cytomegalovirus;
- CTL :
-
Cytotoxic T-lymphocytes;
- TNP :
-
Trinitrophenol;
- TPA :
-
12-0-Tetrade-canoylphorbol-13-acetate;
- DCC :
-
“Defective in Colon Carcinoma” (surface glycoprotein described by Fearon et al., 1990);
- mAb :
-
Monoclonal Antibody
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© 1993 Plenum Press, New York
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Herrlich, P. et al. (1993). Cd44 and Splice Variants of Cd44 in Normal Differentiation and Tumor Progression. In: Hemler, M.E., Mihich, E. (eds) Cell Adhesion Molecules. Pezcoller Foundation Symposia, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2830-2_17
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DOI: https://doi.org/10.1007/978-1-4615-2830-2_17
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