Long-Term Follow-up of HIV Positive Asymptomatic Patients Having Received Cyclosporin A

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The data of the 27 asymptomatic HIV-1 seropositive patients with CD4 + cell count between 300 and 600/µl treated by Cyclosporin A (CSA) (7.5 mg/kg/day) in our institution between october 1985 and 1987 were rewiewed in October 1993. Hemoglobin concentration, platelet count, total lymphocytes, CD4+ and CD8+ cell counts and serum core protein p24 antigenemia, as well as creatininemia measured before CSA onset, at CSA cessation and twice a year were recorded as well as clinical signs and CSA toxicities. In October 1993 median duration of CSA treatment was 11 months, median follow-up after CSA cessation was 45 months and median total follow-up was 67 months. Toxicities of CSA were those commonly encountered in other pathologies. Under CSA no patient progressed toward clinical AIDS (1987 definition). The mean CD4+ cell count of the 27 patients remained unchanged (gain of 1 cell/year) under CSA treatment, while it decreased at a rate of 50 cells/year after CSA cessation (p<0,005). On the other hand CSAtreatment had no significant impact on the evolution of total lymphocyte count, CD8+ cell counts, and P24 antigenémia.