Chapter

Cell Activation and Apoptosis in HIV Infection

Volume 374 of the series Advances in Experimental Medicine and Biology pp 217-228

Cyclophilin and Gag in HIV-1 Replication and Pathogenesis

  • Ettaly Kara FrankeAffiliated withDepartment of Medicine, Columbia University College of Physicians and Surgeons
  • , Jeremy LubanAffiliated withDepartment of Medicine, Columbia University College of Physicians and Surgeons

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Abstract

The gag gene products perform many functions in the retroviral life cycle. Recent work suggests that specific binding of HIV-1 Gag to the cellular proteins known as the cyclophilins is necessary for viral infectivity and perhaps of importance to the immunopathology associated with HIV infection. Cyclophilins are ubiquitous prolyl isomerases thought to function as chaperones. Members of this family of proteins are required for the immunosuppression induced by cyclosporin A and are suspected regulators of cellular activation pathways. Here we review the functions of the gag proteins, what is known about the Gag-cyclophilin interaction, and the possible relevence of this interaction for HIV-1 replication and pathogenesis.