Checkpoints in the cell cycle from a modeler’s perspective

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Abstract

The cell division cycle is a complex process by which cells grow and divide into two viable daughter cells. So that mistakes are not made in this crucial replication process, cells stop at one or more “checkpoints” in the cycle to query their internal state and external conditions, before proceeding to the next stage of the cycle. In this paper we study some simple mathematical models of cell cycle arrest in G1 (“Start”) and G2. Our models help to relate the molecular mechanisms of these checkpoints with physiological properties of the cell cycle.