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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5

Volume 507 of the series Advances in Experimental Medicine and Biology pp 117-121

Calcium Binding to 5-Lipoxygenase

  • Tove HammarbergAffiliated withDepartment of Medical Biochemistry and Biophysics Karolinska Institutet
  • , Konda Veera ReddyAffiliated withDepartment of Medical Biochemistry and Biophysics Karolinska Institutet
  • , Bengt PerssonAffiliated withDepartment of Medical Biochemistry and Biophysics Karolinska Institutet
  • , Olof RádmarkAffiliated withDepartment of Medical Biochemistry and Biophysics Karolinska Institutet

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Abstract

Human 5-lipoxygenase (5L0) catalyzes the rate determining step in the cellular production of leukotrienes and lipoxins and has therefore become an important target for pharmacological treatment of inflammatory disorders (1). Regulation of 5L0 activityin vivois complex and has been shown to involve processes such as translocation to membrane structures, redox status and the presence of certain levels of calcium ions and ATP, for review see (2).