Calcium Binding to 5-Lipoxygenase

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Abstract

Human 5-lipoxygenase (5L0) catalyzes the rate determining step in the cellular production of leukotrienes and lipoxins and has therefore become an important target for pharmacological treatment of inflammatory disorders (1). Regulation of 5L0 activityin vivois complex and has been shown to involve processes such as translocation to membrane structures, redox status and the presence of certain levels of calcium ions and ATP, for review see (2).